Abstract: This study examined the influence of monitoring and evaluation (M&E) practices on healthcare delivery in public health facilities of Kisumu Central Sub-County, Kisumu County, Kenya. The study employed a mixed-methods convergent parallel design with both quantitative and qualitative approaches. The sample consisted of 200 healthcare professionals selected using Yaman’s formula and purposive sampling for managers. The study was anchored on Conceptualization of the Program theory by Weiss. The study considered the 4 hospitals in Kisumu Central Sub-County, Kisumu County, Kenya making a total population of 400. Data were collected through questionnaires and interviews, analyzed using SPSS (v26) for descriptive statistics and multiple regression, and thematic analysis for qualitative data. Key findings revealed that 55.1% of respondents agreed that M&E systems were established, yet only 50.3% found that, data management were effective for decision-making. Barriers included inadequate time for data review (62.6%), lack of interpretation skills (25.1%), and limited access to reports (12.3%). The study concludes that strengthening data management capacity, enhancing feedback mechanisms, and promoting timely report use are critical for improving healthcare delivery. The study recommended customization of Health Management System to facility-specific needs, capacity building for staff, continuous mentorship, and support on internet connectivity and backup power systems. 

Keywords: Monitoring and Evaluation, Practices, Healthcare Delivery, Public Health Facilities, Health Systems Management