The Food and Agricultural Organization (FAO) code of conduct documents sustainable fishing as a small-scale method with social, economic and environmental benefits, in that it respects marine ecosystem and adapts to the reproductive rate of fish to maintain a balance and ensure the survival of all species, (Hudson, 2012). Water hyacinth (Eichhornia Crassipes) is an aquatic plant which lives and reproduces both sexually and asexually, and it floats freely on the surface of fresh waters or it can be anchored in mud, (Ndah, 2009). This study set out to examine the influence of water hyacinth on fish trade in the lakeside community of Kisumu West Sub County, Kenya. The study was grounded on opportunity based entrepreneurship and sustainability theories. The study targeted a population of 172,821 in which a samples size of 100 was drawn. A case study design was employed to single out the lakeside community of Kisumu West Sub County. The study used questionnaires, focused group discussion guides and key informant guides to collect data. The findings reveal that 41% of the respondents confirmed that water hyacinth impinge on fish trade. The study discovered that the weed can be transformed as an economic resource where it acts as a breeding ground for fish. The study recommended the need for the implementers of water hyacinth projects to guarantee humble time by involving the community members at the identification and the planning stages. Key words: Economic resource, opportunity based entrepreneurship, sustainability, water hyacinth, survival of all species, marine ecosystem